Posted to MedZilla on 2/16/2020


Takeda Pharmaceuticals

US-MA, Analytics and Bioassays Lead, Global Gene Therapy Research SR0044511-MZ


 
 

Are you looking for a patient-focused company that enables transformative technologies to address patients needs while inspiring you and support your career?

Takeda is a world-class organization where we combine our expertise in disease biology, modality technologies and drug development experience to develop gene therapies in a holistic approach. We are seeking a highly motivated leader with substantial experience in vector design and gene therapy drug development experience to join Takeda to advance our gene therapy research effort.

Be empowered and join us as an Analytics and Bioassays Lead Research Principal Scientist in the Global Gene Therapy Research Team.

OBJECTIVES:

As the Analytics and Bioassays Lead Research Principal Scientist, the incumbent will be responsible and accountable for the execution of experiments and coordination with CROs to perform analytical and bioassays on test articles for gene therapy projects.

ACCOUNTABILITIES

  • Genomic DNA and RNA isolation from viral vectors, cells and tissues.
  • Perform PCR-based assays (qPCR, RT-qPCR, ddPCR, etc) with high technical standard with competent and reproducible results.
  • Analyse data to provide an interpretation of results with appropriate biostatistical analysis.
  • Documentation of experimental details in the form of electronic labnotebook (eLN) and study reports.
  • Present experimental designs, protocols, results and interpretations in group meetings, project team meetings and/or departmental meetings in PowerPoint format.
  • Independently design and execute cell-based assays to assess the function of gene therapy products.
  • Handle multiple tissue cell type mammalian cell culture, and conducting cell based experiments TCID50, transduction, transfection and genetic modification in cell lines and potency assays.
  • Evaluate and implement new analytical technologies for gene therapy products.
  • Serve in project subteam and lead communications between Research and Pharm Sci at the time of development transition.
  • Establish connection with internal and/or external CRO for assay transfer with assay and biology expertise
  • Assist in internal communication between GGT and Pharm Sci, and external communication where assays are transferred to external CRO organizations.
  • Make detailed observations, produce competent and reproducible results to a high technical standard, analyze data to provide an interpretation of results.
  • Must be detail-oriented with good organization skills, maintain accurate and well-organized laboratory records.
  • Positive attitude with strong focus on hands on lab work to generate reproducible assay results.
  • Follow compliance of documentation in electronic lab notebook and author scientific reports that supports internal documentation and regulatory submissions.
  • Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals

Technical/Functional (Line) Expertise

  • Outstanding expertise and depth of knowledge within a scientific area
  • Keeps up with the up-to-date scientific advancement (e.g. competitive landscape, new technology, new research portfolio, and new partnership)

Leadership

  • Plays a leading scientific role on project team(s), setting high standards for rigor of thought.

Decision-making and Autonomy

  • Independently manages workload and expectations
  • Scientifically independent
  • Scientific driver for research strategy that impacts group internally and outside area of the function

Interaction

  • Initiates and leads external interactions and collaborations
  • Frequent contact with internal and external personnel at various management levels

Innovation

  • Determines methods on new assignments; makes strategic recommendations on projects

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • PhD degree in a scientific discipline with 8+ years experience.
  • Minimum 2 years of relevant experience in bioanalytical and analytical characterization of nucleic acid (DNA, RNA, oligos, etc) with viral and/or non-viral delivery vehicle use in research and development.
  • Proficiency in mammalian cell culture and aseptic cell culture tehniques.
  • Experience in the development of molecular biology test methods not limited to PCR (qPCR, ddPCR), TCID50, transduction assay, protein quantification assays such as ELISA, SDS Page, quantitative PCR method, capillary Electrophoresis, AUC, and cell based assays.
  • General molecular biology knowledge and skills (genomic DNA and RNA isolation from virus, cells and tissues.
  • Previous wet lab experience or equivalent education in Real Time PCR based laboratory techniques is desired, familiarity with qPCR platforms, expertise in qPCR optimization and data analysis is required.
  • Follow compliance of documentation in electronic lab notebook and author scientific reports that supports internal documentation and regulatory submissions.
  • Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals.
  • Ability to balance multiple projects under a demanding timeline.

Notice to Employment / Recruitment Agents:

Employment / Recruitment agents may only submit candidates for vacancies only if they have written authorization to do so from Shire, a wholly-owned subsidiary of Takeda s Talent Acquisition department. Any agency candidate submission may only be submitted to positions opened to the agency through the specific Agency Portal. Shire, a wholly-owned subsidiary of Takeda will only pay a fee for candidates submitted or presented where there is a fully executed contract in place between the Employment / Recruitment agents and Shire, a wholly-owned subsidiary of Takeda and only if the candidate is submitted via the Agency Portal. Candidates submitted or presented by Employment / Recruitment Agents without a fully executed contract or submitted through this site shall not be deemed to form part of any Engagement for which the Agency may claim remuneration.

Equal Employment Opportunity

Shire, a wholly-owned subsidiary of Takeda, is an Equal Opportunity Employer committed to a diverse workforce. Shire, a wholly-owned subsidiary of Takeda, will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

EEO is the Law - https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf

EEO is the Law Supplement - https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCP_EEO_Supplement_Final_JRF_QA_508c.pdf

Pay Transparency Policy - https://www.dol.gov/ofccp/pdf/pay-transp_formattedESQA508c.pdf

Reasonable Accommodations

Shire, a wholly-owned subsidiary of Takeda, is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.


Please visit our website at takedajobs.com

 
 


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