Posted to MedZilla on 2/22/2020

Takeda Pharmaceuticals

US-CA, Sr. Scientist - ENS Biology R0015053-MZ


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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Sr. Scientist - ENS Biology at our recently dedicated San Diego Research Site.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission. As a Sr. Scientist - ENS Biology, you will be empowered to serve on project teams for discovery to development programs.


  • Independently designs, develops and executes research assignments contributing to multiple projects, acting as senior scientific consultant or as manager of a matrix project team
  • Lead the design, execution, and interpretation of data relating to studies assessing the function of the enteric nervous system (ENS) in support of drug discovery programs and research efforts.
  • Apply expertise in ENS biology on discovery project teams, may lead discovery programs, and will oversee junior laboratory staff.
  • Drive collaboration with external partners, including industry, CRO, and academic to run functional GI studies and answer key research questions around ENS biology


  • Designs and performs ex vivo GI motility studies for the testing of novel therapeutics
  • Works independently to develop and optimize methodologies for ex vivo GI motility studies aligned with strategic goals
  • Leads a lab-based team of technicians to perform experiments assessing function of the ENS
  • Collects, analyzes, interprets and presents data and participates in decision-making in project teams
  • Identifies novel drug targets and leads efforts to design and complete studies for recommendation of pursuing a target for drug discovery
  • Serves as discovery project team leader and/or team member
  • Interacts with external academic and industry partners; lead external collaborations/alliances
  • Works cross-functionally with internal teams and external partners to achieve project goals

Technical/Functional (Line) Expertise

  • Track record of high impact publication in the field of GI motility and physiology
  • Significant expertise in functional ex vivo GI motility methods including organ bath pharmacology, spatiotemporal mapping, and motility assays
  • Experience with other functional GI assays such as Ussing chamber, in situ Ca2+ imaging, and electrical nerve recordings
  • Ability to develop new methodologies within expertise in order to meet project objectives
  • Acts as the recognized scientific expert in ex vivo GI pharmacology and functional motility studies
  • Background in in vivo rodent work and in vitro cell culture also a plus
  • Demonstrates effective project management skills


  • Develops and oversees scientific projects and will manage the work of others directly or in a matrixed structure
  • Demonstrated leadership / management experience in lab-based and/or other scientific-based settings.
  • Mentorship, talent development, and teaching experience also favorably considered.

Decision-making and Autonomy

  • Independently manages workload and expectations
  • Scientifically independent and stays abreast of current literature in field
  • Demonstrated examples of decision-making that directs project goals and outcomes


  • Collaborates with others, and acts as scientific resource for ex vivo functional GI motility studies
  • Highly engaged with the external environment, academic field, and technological landscape
  • Attends relevant international / national scientific conferences in the field of Gastroenterology and ENS biology


  • Receives high level instructions from departmental managers, interpedently determines methods
  • Independently identify opportunities for incorporating novel methods and technology, establishing capabilities, and optimizing
  • Manages direct reports and delegates effectively


  • PhD degree in a scientific discipline with 5+ years experience, or
  • MS with 10+ years experience, or
  • BS with 12+ years experience
  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

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San Diego, CA

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Full time

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