Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Medical Director, Translational Sciences Medical Oncology in our Cambridge office.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Futureto people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
This is a highly collaborative role involving cross-functional collaborations across immuno-oncology programs, small-molecular programs, and/or disease-focused programs in conjunction with the clinical development teams at Takeda Oncology in Cambridge, MA. The overall goal will be to develop and support an asset and/or program-specific translational strategy, assimilate discovery findings during pre-clinical development to rationally inform the development of clinical biomarker and patient stratification strategies, and contribute to proof-of-concept and mechanistic evaluation of assets in the pre-clinical and clinical space, including with representation on Global Project Teams for early-phase clinical trials. This role will also involve leadership of physician-scientists within the Translational Sciences team.
Serve as a key leader within Oncology Translational Sciences
- Integrate into multi-disciplinary project teams to develop and support translational strategies that bridge between discovery and development efforts
- Provide cross-functional expertise in translating research findings from pre-clinical model systems to clinically-relevant biomarker signatures and patient stratification strategies
- Utilize clinical expertise to leverage the integration of clinical thinking into biomarker selection strategy for pre-clinical and early clinical programs; will provide leadership and management for group of physician-scientists in Translational Sciences team
- Embed in Oncology Discovery project teams at project launch, guide the team s translational strategy through preclinical development to FIH trials and efficacy proof-of-concept (ePOC), support the research path into clinical development, and focus on opportunities for reverse translation.
- Work in a matrixed, cross-functional environment with key member functions of discovery and development teams during preclinical and early clinical development to drive implementation of translational strategy for the project. These functions include but are not limited to Discovery Biology, Discovery Chemistry, Global Biologics Research, Drug Safety Research and Evaluation, DMPK, Modelling, Oncology Clinical Research, Clinical Pharmacology, Clinical Biomarkers, Biostatistics, Regulatory, Clinical Operations, Medical Affairs, Commercial.
- Serve as key liaison to connect with representatives from the Oncology Translational Genomics and Integrated Translational Technologies groups based upon project team needs in order to leverage patient datasets, patient samples, and diverse methodologies to support the translational blueprint. This will extend to coordinating translational strategy prior to IND to develop the more detailed clinical strategy including clinical biomarker implementation.
- Build and develop a translational blueprint (MOA relevance in disease area, competitive differentiation, indication selection, patient stratification, combination strategy, PD biomarkers) and go/no-go criteria to move through key project stage gates.
- When indicated, support a reverse translation plan to enable seamless flow of knowledge from the clinic back to the project team as well as other projects within the immune-oncology pipeline.
- Partner with the project team in the selection and engagement of external collaborators/KOLs to guide the translational strategy across the discovery-development continuum.
- Integrate knowledge from diverse sources to inform translational hypothesis generation, will identify models suitable to testing hypotheses, contribute to the design of experiments, and coordinate execution and data analysis.
- Serve as a critical knowledge base for project teams on the standard of care and the clinical landscape in disease areas of relevance, and the competitive landscape in mechanisms of relevance. Contribute to drafting and developing strategic approach to clinical strategy across platforms and pathways of interest. Depending upon interest and need, may also contribute to clinical development of protocol and trial monitoring, working in cross-functional global project team (GPT).
- Contribute to key documentation and presentations for projects moving through internal review stage gates and regulatory submissions.
- Serve as an internal thought leader in clinical area(s) of expertise and drive strategy development for specific disease indications centered around biomarkers (defined and emerging) and mechanism-of-action of portfolio agents
- Collaborates with others, and acts as scientific and clinical resource for an aspect of a program
- Participates in external interactions and collaborations
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
- MD, or internationally recognized equivalent degree, list of publications, grants, research awards etc)
- Board certification in Medical Oncology preferred
- Clinical patient care experience in medical oncology preferred
- Excellent oral and written communication skills, including writing, reviewing and editing scientific documents
- Superior interpersonal skills, diplomacy and positive influencing abilities
- Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams
- Good fit with Takeda core values and leadership principles
- Right attitude (agile, curious, open-minded, can-do mindset)
- Superior therapeutic area knowledge and solid understanding of emerging research in designated therapeutic area (if applicable)
- Ability to drive to or fly to various meetings or R&D sites including overnight trips
- Ability to spend longer period of time at a different R&D site (weeks or several months)
- Some international travel may be required.
WHAT TAKEDA CAN OFFER YOU:
- 401(k) with company match and Annual Retirement Contribution Plan
- Tuition reimbursement Company match of charitable contributions
- Health & Wellness programs including onsite flu shots and health screenings
- Generous time off for vacation and the option to purchase additional vacation days
- Community Outreach Programs
Empowering Our People to Shine
Discover more at takedajobs.com
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