Posted to MedZilla on 1/23/2019

Takeda Pharmaceuticals

US-MA, Associate Scientist, Translational Technologies R0006126-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Associate Scientist, Translational Technologies in our Cambridge office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Associate Scientist, Translational Technologies working on the Translational Science team, you will be empowered Develop immunohistochemistry assays and engage with project teams to execute research strategies supporting target/ drug interaction , and a typical day will include:


- Establish tissue-based scientific methodologies for target discovery/validation, therapeutic modality differentiation, and mechanism of action analysis

- Deliver state-of-the-art oncology pathology/biomarker analysis in support of discovery stage and early clinical stage therapeutics

- Collaborate with related functions including protein sciences, pharmacology, cytometry-based profiling, drug safety, translational sciences and bioinformatics

- Interact with external vendors to outsource selected Immunohistochemistry assays and analysis for Discovery projects


- Develop immunohistochemistry assays utilizing human and animal model tissue for profiling oncology and immuno-oncology target expression.

- Profile primary human tumors for target mapping and reverse translation to inform clinical indication for targets

- Develop multiplex immunohistochemistry and fluorescence assays, perform digital visualization and analysis methods to assess complex cellular phenotypes including immune cell involvement in pre-clinical and clinical tissue samples

- Help procure and maintain human tissue bank within Translational Technologies in conjunction with departmental colleagues.

- Perform experimental execution, data presentation and interpretation for target tissue mapping and

mechanism of action/biomarker analyses for specific projects/targets

- Engage with project teams to execute research strategies supporting target/ drug interactions, identification of immune components in model systems, and biomarker identification and validation.

- Communicate and collaborate effectively with departmental colleagues as well as cell biologists, pharmacologists,

information technologists and external partners in a cross-functional, collaborative team environment

- Appropriately document and report data to support regulatory filings

- Review data from external vendors

- Responsibilities include 60-70% lab work and 30-40% outsourcing support activities


- BS with >2 years experience related to Immunohistochemistry, target validation, mechanism of action, pharmacodynamic, and translational strategies for immuno-oncology and antibody based therapeutics

- Knowledge of oncology biology, including immuno-oncology

- Familiarity with human and animal tissue histology preferred

- Demonstrated expertise in histology/biomarker techniques relevant to oncology drug discovery

- Experience in automated assay development (Lieca, Ventana) and analysis of markers in human and animal tissue specimens (Halo) is strongly preferred.

- Excellent written and verbal communication and presentation skills

401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs
Empowering Our People to Shine
Learn more at
No Phone Calls or Recruiters Please.



Boston, MA

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Full time

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