Sci I/II, Lead Discovery
The Lead Discovery group within ImmunoOncology Research at Takeda Boston is seeking a Cell Biologist/Immunologist with extensive cell based assay development experience to progress small/large molecule programs into the clinic. The successful candidate will also independently design and implement experiments to address mechanisms-of-action of therapeutic molecules. The research scientist will also be responsible for participating on matrix project teams, interfacing very closely with members of the Protein Sciences/Immuno Biologics/ Chemistry/IO Biology teams.
- Provide broad assay development support for early stage drug discovery projects in the field of Oncology/IO
- Collaborate with engineers to identify suitable approaches for assay automation and execute high throughput small molecule/large molecule screens
- Design, execute and validate a variety of assays to understand mechanism of action of compounds and characterize different biologics
- Contribute and implement new ideas and in vitro proof of concept studies to enable initiation and progression of early discovery projects
- Interface with project teams to meet timelines for project progression
- Evaluate and implement the best assay technologies in collaboration with project teams to fit the purpose at hand
- Present research findings clearly and effectively at internal and external meetings
- Support drug discovery programs by providing relevant scientific and strategic input to drive project decisions
- Manage resource allocation across programs based on needs and prioritization
- Troubleshoot complex problems in creative and effective ways and actively participates in innovation and/or optimization of established processes to ensure delivery on project goals
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
- MS/PhD in Biochemistry/Cell Biology/Immunology with Post-Doc experience or 2+ years of relevant experience or equivalent, in early stage pharmaceutical drug discovery
- Team player able to liaise across multiple disciples including Automation, Cell Biology, Chemistry, Compound Management and Immunology
- Self-motivated, collaborative with excellent time management and organizational skills
- Skilled in analysis, interpretation, and presentation of results
- Experience with mammalian cell culture with best practices in tissue culture is required
- Hands on experience with automated platforms
- Excellent written and verbal communication skills, along with the ability to work in cross-functional project teams
- Innovative and critical thinking
- Ability to advance multiple projects in a fast paced environment
- Manual dexterity required to operate office equipment (i.e., computers, phones, etc.).
- Carrying, handling and reaching for objects up to 25 lbs.
- Working in a lab environment: standing, walking, bending, etc.
- Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
- Requires approximately 0-5% travel