Posted to MedZilla on 10/22/2018

Takeda Pharmaceuticals

US-CA, Research Associate II - Neuropharmacology - San Diego, CA R0004415-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Research Associate II, Neuropharmacology in our San Diego, California office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Research Associate II, Neuropharmacology on the Neuroscience Drug Discovery team, you will be empowered to perform brain dissections, survival surgery, video and EEG monitoring, analysis of seizures in rodents and ex vivo analysis of tissue


  • The Research Associate II, Neuropharmacology (RAII) should be able to independently provide in vivo and ex vivo pharmacology support to Takeda, California portfolio programs within Neuroscience Drug Discovery Unit. This includes: rodent handling, dosing, survival surgery, neurobehavior studies, tissue dissection and sample processing,


  • The Research Associate II will perform brain dissections, survival surgery, video and EEG monitoring, and analysis of seizures in rodents. This individual will formulate drugs, dose small rodents (mice/rats) through various routes of administration (IP, PO, SC, ICV) in a stress-free manner for low variability between studies, conduct behavior tests, conduct serial sample collections as well as terminal collection of all tissues for biomarker and PK/PD analysis.
  • Work independently to establish and validate protocols not yet set up in-house on as needed basis as well as troubleshoot issues by reviewing literature.
  • Accurately follow protocols, record detailed observations and data in electronic notebook system, create summary reports for the projects and communicate results to the teams.
  • Manage priorities and set appropriate weekly workload for the in vivo studies and train junior personnel to perform studies.
  • Participate in training programs, review and study literature and design experiments, and provide updates at project meetings as appropriate.
  • Coordinate with project leaders to set acceptable timeline for each project based on urgency and resource limitations and communicate with the upstream and downstream of in vivo study processes as demanded by projects to provide meaningful and desired data.
  • Maintain the operation of the in vivo laboratory according to established standards and in legal compliance.
  • Perform general lab support duties including preparation of solutions, ordering supplies, and maintaining lab equipment.


  • MS in Neuroscience, Pharmacology or related field with at least 0-2 years laboratory research experience OR BS in Neuroscience, Pharmacology or related field with at least 2-5 years laboratory research experience
  • Highly competent in animal handling, dosing compounds to animals, tissue collection and familiarity with CNS biology
  • Experience in drug discovery, particularly neuropharmacology studies in animal models of disease
  • Experience in survival surgery of rodents (rats/mice)
  • Experience in EEG data processing and analysis is a plus
  • Experience in tissue sectioning, staining and image analysis will be beneficial
  • Experience in qPCR, western blot, immunoassays as well as receptor occupancy and autoradiography
  • Skilled in statistical analysis, graphing programs like Graphpad Prism, PowerPoint presentations and Excel
  • Excellent written and verbal communication skills and possess the ability to work independently as well as part of a team
  • Ability to design and interpret experiments collaboratively and independently
  • Ability to manage multiple tasks and priorities to achieve desired goals
  • Excellent attention to detail


  • Carrying, handling and reaching for objects up to 25 lbs.
  • Able to work in a lab environment
  • Exposure to hazardous and toxic chemicals
  • Potential exposure to rodent allergens


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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