Posted to MedZilla on 4/24/2017

Takeda Pharmaceuticals

US-CA, Principal Scientist - Biophysics 1700444-MZ


Leads a team of biophysical chemists to advance company projects and priorities while meeting the highest standards of operational and scholarly excellence. Implements a rigorous molecular, analytical, and physical chemistry perspective in the development of therapeutic monoclonal antibodies and the screening of fragments and small molecules to various protein targets.


  • Leads, inspires and motivates a creative team of Biophysics personnel in routine day-to-day operations.
  • Demonstrated expertise in NMR, SPR, MS, ITC, Tm and other biophysical techniques. Demonstrated expertise in applying these techniques to antibody, fragment and small molecule research
  • Implements the best biophysical practices and innovations, assists in the assessment of technologies, and methodologies for in-licensing and integration to enhance biophysically efficiencies and quality.
  • Collaborates with scientists from other research functions to ensure timely progress in research projects and presents project updates to management.
  • Implements exploratory research to support identification and characterization of antibodies, small molecules or fragments; conducts extended studies to investigate the mechanism of action as related to the binding of mAb to target antigen or small molecule fragments to protein targets.
  • Maintains a current understanding of the analytical literature, as well as the scientific literature related to specific drug discovery projects.
  • Prepares and organizes data for presentation. Presents written and oral reports to management. Communicates research efforts to collaborators, corporate partners, or at scientific meetings.
  • Coordinates and manages resources within the Biophysics Group for drug discovery projects in order to ensure timely achievement of goals.
  • Makes a significant impact within project teams to advance programs from early phases to developmental phases.
  • Recognized as an internal expert in the area of biophysical characterization of monoclonal antibodies and the screening of fragments.
  • Publishes original research and review articles in scholarly journals in order to build the reputation of Takeda California and the Biophysics Group.
  • Serves as an intra-company consultant for all biophysical issues that may arise during the drug development process.
  • Identifies opportunities to collaborate with partners (academic, biotech and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively.
  • Provides supervision and support to new endeavors as assigned.


  • Ph.D. in Physical Science with thesis, publication(s), postdoctoral experience, and a minimum of 8 years relevant scientific and technical experience including industry experience OR MS with 18+ years of experience OR 20+ years of relevant experience
  • Knowledgeable in all biophysical and analytical aspects of drug discovery from target discovery through early clinical development.
  • Track record of efficiency and productivity of non-clinical analytical and biophysical characterization in drug development programs, including antibodies and fragments, from leads to clinical candidates.
  • Demonstrated ability to work in a dynamic start-up environment and matrix organization.
  • An expert in biophysical and analytical biochemistry issues related to drug discovery and its applications to protein drugs, specifically therapeutic monoclonal antibodies and small molecules or fragments.
  • Positive can-do attitude with strong collaboration skills and ability to work with drug discovery scientists.
  • Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Demonstrated interest in applying biophysical solutions in fragment based drug discovery.
  • Professionally represents the organization in collaborations, partnership discussions, and external relationships and conferences
  • Proven track record of scientific contributions in life science as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates
  • Novel problem solver for any obstacles that may be encountered in the molecular or chemical characterization of therapeutic monoclonal antibodies or small molecule fragment screening.
  • Excellent written and verbal communication skills.

  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
  • Requires approximately 5% travel.

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