Posted to MedZilla on 5/23/2017

Takeda Pharmaceuticals

US-MA, Scientist II/I, Immunology Research 1602953-MZ



  • Based in Cambridge, MA, the role is a lab-based research scientist who will work on cutting-edge Immuno-Oncology programs in highly matrixed and collaborative environment that relies on close interactions with Oncology teams as well as external academic, biotech, and clinical partners.
  • The scientist will support the progression of a cutting-edge, externally-enabled Immuno-Oncology portfolio and will influence the therapeutic area strategy through data generated and intellectual contributions.
  • The Scientist I provides theoretical/conceptual input to the design, development and execution of a well-defined specific project.


  • Work with various pre-clinical models of xenograph/syngeneic mouse tumor models, including the utilization of appropriate genetically modified mouse strains.
  • Independently operate, for immune phenotyping, flow-cytometers such LSR Fortessa II and cell sorting on the BD FACSAria II/III.
  • Design new protocols for sorting and optimize sorting parameters along with verification of sorting purities/efficiencies. Understand compensation and the complexities of polychromatic flow cytometry from 6 -18 colors.
  • Establish and validate work stream for isolating various subsets of immune cells from various immune organs to single cell profiling by flow cytometry and transcript analysis.
  • Independently analyze data, including FACS data, with interpretation of results and proposals for next steps.
  • Able to present data in a succinct fashion in various settings (lab meetings, journal clubs, leadership meetings)
  • Maintain accurate, complete, and timely data in laboratory notebooks.



  • Ph.D. in Immunology from world-renowned laboratory, or equivalent.
  • Publications in peer-reviewed journals demonstrating expertise and achievements in the Immunology field.
  • A sufficient knowledge of Immunology to be reasonably self-directed in establishing immune-profiling assays in the context of tumorigenesis.
  • Experience working with primary human cells and tissues.
  • Experience working with mouse models in the context of immune or cancer biology, including hands-on experience with ex vivo isolation and manipulation of various immune cell subsets from mouse tissues.
  • Experience carrying out T cell functional assays, including evaluating responses to specific antigens.
  • Experience culturing and manipulating primary innate immunocytes (macrophages, dendritic cells).
  • Hands-on experience and ability to work with minimal supervision in carrying out FACS analysis with cytometers such as LSRII, FACS CANTO, and FACS ARIA II/III.
  • Proficiency in molecular/immunological assays such as ELISA/Luminex, qRT-PCR and TR-FRET.
  • Working experience utilizing public genomic databases to identify targetable pathways in various disease indications is a plus.
  • Good communications skills, both oral and written.
  • Good listening skills, but also not afraid to speak up!
  • Excellent analytical, organizational, interpersonal and time management skills.
  • Strong team player who thrives in a dynamic, biotech-like environment.

Requires some travel, including international

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