US-CA, Associate Scientist, Target Discovery 1602072-MZ
Designs and executes in vitro and in vivo/ex vivo experiments using molecular biology, biochemical, pharmacological or genetic methods to identify and validate novel drug targets with a focus on GI disease area
Characterizes bacTRAP mouse lines using qPCR, immunofluorescence and immunohistochemistry
Designs and executes in vivo studies in relevant disease models, performs ex vivo TRAP experiments including tissue dissection, RNA preparation and amplification, quantitative RT-PCR and RNA-sequencing
Participates in novel drug target identification activities through gene expression profiling, data analysis, public database mining, and literature search
Conducts target validation experiments using a variety of molecular and biochemical methods
Provides analysis and interpretation of data, presents data and project update effectively in department meetings
Proactively manages colonies of transgenic mice and RNAseq activities through CROs
Maintains concise, accurate, and comprehensible written records as per Takeda
Works exceptionally well with others in a fast paced and team environmentQualifications
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
MS with 8 or more yrs or B.S. with 10+ yrs. of relevant laboratory experience.
Expertise and extensive experience in molecular and cellular biology, biochemistry, immunohistochemistry and immunofluorescence microscopy.
Hands-on experience in small animal pharmacology and ex vivo assays including dosing, tissue collection, tissue RNA preparation and amplification, tissue gene expression profiling by qPCR.
Knowledge and experience of analyzing RNAseq data and identifying novel drug targets is preferred.
Experience of working with CROs
Ability to work exceptionally well with others in a fast paced, dynamic, and team environment
Excellent communication and organizational skills
Carrying, handling and reaching for objects up to 25 lbs.
Able to work in a lab environment
Willingness and ability to travel occasionally to other research sites
we are driven to improve people's lives
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